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Pathophysiology of Chronic Pancreatitis

Pathophysiology of Chronic Pancreatitis

Pancreatitis (inflammation of the pancreas) is a serious disease of the pancreas with an intensity that can range from relatively mild disorders and self-limiting disease goes up quickly and fatal not react to various treatments. (Brunner, Sudarth, 2002, KMB)

Chronic pancreatitis is an inflammation of the pancreas characterized by destruction of the anatomical and functional progressive in the pancreas.

Pathophysiology of Chronic Pancreatitis

Consumption of alcohol is too long will result in the destruction of pancreatic cells and the formation of protein blockage. Destruction as a result of alcohol will result in injury to the pancreas are replaced with connective tissue. Formation of connective tissue will increase the pressure in the pancreas. Both the formation of connective tissue and blockage of protein will result in mechanical obstruction on pancreatic duct, choleductus, and duodenum. This condition would be aggravated by atrophy of ductal epithelium, inflammation as a result of irritation of the pancreatic secretion.

Pancreatic obstruction will result in distension of the pancreas that stimulates the pain receptors that can spread to the abdominal area and back. These conditions gave rise to complaints of severe abdominal pain radiating to the back.

Damage that occurs in the pancreas can systematically improve the response of gastric acid as one of defense to reduce the level of damage. However, this advantage will only stimulate gastric response to increase rhythmic contractions that can increase nausea and vomiting. In addition to the decrease in pancreatic secretion due to damaged cells will also have an impact on the decline or impaired absorption of food. Conditions nausea, anorexia, impaired absorption of food will result in meeting the needs of people with impaired nutrition.

Decreased secretion of pancreatic involvement will not affect the protein and good fats. Faecal fat will contain many elements that cause a froth, the stench in feces and increased frequency of defecation.